TY - JOUR JO - EuroIntervention TI - Feasibility, safety and diagnostic impact of endomyocardial biopsies for the diagnosis of myocardial disease in children and adolescents AB - <p class="text-1er-paragraph"><span class="abstracts-titres">Aims:</span> Endomyocardial biopsies (EMBs) are performed infrequently in children owing to significant past complication rates and controversial discussions about the therapeutic value of results. The objective of this study was to investigate the safety and feasibility of EMBs for suspected myocardial disease in relation to their clinical value.</p><p class="text-1er-paragraph"/><p class="text-1er-paragraph"><span class="abstracts-titres">Methods and results:</span> We performed a retrospective multicentre review of the Working Group for Interventional Cardiology of the German Society for Paediatric Cardiology. During three consecutive years, 206 EMBs (84 female/mean age 8.95±6.62 years) were performed and analysed at 15 heart centres. In the majority of cases, biopsies were taken from the right ventricle (RV/89.8%; p&lt;0.001). The overall complication rate was 9.7%, whereas major complications occurred in only 0.97% of cases. Risk factors associated with a higher complication rate were biopsy during the first year of life (20.5%) and from the left ventricle (31.1%) (p&lt;0.05). There was no procedure-related mortality. Treatment was changed in 18.0% of cases based on biopsy results.</p><p class="text-1er-paragraph"/><p class="text-1er-paragraph"><span class="abstracts-titres">Conclusions:</span> Today, endomyocardial biopsies in older children with suspected myocardial disease can be performed safely with a low risk of major complications and mortality, whereas the risk of complications if the biopsy is carried out in the first year of life or taken from the left ventricle remains high.</p> AU - Mueller Goetz C. AU - Michel-Behnke Ina AU - Knirsch Walter AU - Haas Nikolaus A. AU - Abdul-Khaliq Hashim AU - Gitter Roland AU - Dittrich Sven AU - Daehnert Ingo AU - Uhlemann Frank AU - Schubert Stephan AU - Tarusinov Gleb AU - Happel Christoph M. AU - Bertram Harald AU - Sieverding Ludger AU - Eicken Andreas AU - Kozlik-Feldmann Rainer AU - Weil Jochen VL - 14 IS - 10 Y1 - 20/11/2018 Y1 - 2018 DOI - 10.4244/EIJ-D-18-00128 SP - 1089 EP - 1095 KW - access site KW - bleeding KW - clinical trials KW - death KW - pericardial effusion KW - risk stratification PB - Europa Digital & Publishing SE - INTERVENTIONS FOR VALVULAR DISEASE AND HEART FAILURE UR - https://eurointervention.pcronline.com/article/feasibility-safety-and-diagnostic-impact-of-endomyocardial-biopsies-for-the-diagnosis-of-myocardial-disease-in-children-and-adolescents SN - 1774-024X ER -