TY - JOUR JO - EuroIntervention TI - Transcatheter aortic valve implantation using the ACURATE neo in bicuspid and tricuspid aortic valve stenosis: a propensity-matched analysis of a European experience AB - <p class="text-1er-paragraph"><span class="abstracts-titres">Aims:</span> The aim of this study was to assess the performance of a self-expanding valve in bicuspid aortic valve (BAV) stenosis.</p><p class="text-1er-paragraph"/><p class="text-1er-paragraph"><span class="abstracts-titres">Methods and results:</span> An international registry included a total of 712 patients with aortic stenosis treated with the ACURATE <span class="ital">neo</span> in bicuspid (n=54; 7.5%) or tricuspid (n=658; 92.4%) anatomy. The overall mean age was 81±5.6 years. At baseline, no significant differences were found between the two groups. BAV more frequently required both predilatation (94.4% vs. 78.1%, p=0.004) and post-dilation (57.4% vs. 38.7%, p=0.007). Moderate perivalvular regurgitation was more frequently found in patients with BAV (7.4% vs. 3.18%, p=0.0001). After propensity score matching (PSM), the rate of predilation and post-dilation was confirmed to be higher in the BAV group (94.4% vs. 66.6%, p=0.001, and 57.4% vs. 37.1%, p=0.034, respectively), while the incidence of moderate perivalvular regurgitation was similar between the two groups (BAV 3.1% vs. 5.5% in tricuspid anatomy, p=0.734). In unmatched cohorts, the 30-day outcome showed a higher rate of stroke in the BAV group (7.4% vs. 1.8%, p=0.001). After adjustment for PSM quintiles, the rate of stroke resulted in being similar (odds ratio<span class="indice">adj</span> 1.20, 95% confidence interval [CI]: 0.81-1.76, p=0.819). The other 30-day clinical endpoints were similar between the two populations.</p><p class="text-1er-paragraph"/><p class="text-1er-paragraph"><span class="abstracts-titres">Conclusions:</span> This preliminary analysis shows that the use of the ACURATE <span class="ital">neo</span> in bicuspid aortic valves is feasible and has acceptable 30-day outcomes. Larger studies are needed to confirm our preliminary findings.</p> AU - Mangieri Antonio AU - Chieffo Alaide AU - Won-Keun Kim AU - Stefanini G. Giulio AU - Rescigno Giuseppe AU - Barbanti Marco AU - Tamburino Corrado AU - Rück Andreas AU - Pagnesi Matteo AU - Linder Rickard AU - Toggweiler Stefan AU - Montorfano Matteo AU - Colombo Antonio VL - 14 IS - 12 Y1 - 20/12/2018 Y1 - 2018 DOI - 10.4244/EIJ-D-18-00281 SP - e1269 EP - e1275 KW - aortic stenosis KW - degenerative valve KW - miscellaneous KW - paravalvular leak KW - tavi PB - Europa Digital & Publishing SE - INTERVENTIONS FOR VALVULAR DISEASE AND HEART FAILURE UR - https://eurointervention.pcronline.com/article/transcatheter-aortic-valve-implantation-using-the-acurate-neo-in-bicuspid-and-tricuspid-aortic-valve-stenosis-a-propensity-matched-analysis-of-a-european-experience SN - 1774-024X ER -