TY - JOUR JO - EuroIntervention TI - Comparison of acute thrombogenicity for magnesium versus stainless steel stents in a porcine arteriovenous shunt model AB - <p class="text-1er-paragraph"><span class="abstracts-titres">Aims:</span> The present study aimed to investigate whether the Magmaris resorbable magnesium scaffold (RMS) has platelet-repelling properties by comparing its acute thrombogenicity with an equivalent stainless steel stent in an arteriovenous shunt model.</p><p class="text-1er-paragraph"></p><p class="text-1er-paragraph"><span class="abstracts-titres">Methods and results:</span> An <span class="ital">ex vivo</span> porcine carotid jugular arteriovenous shunt was established and connected to Sylgard tubing containing the Magmaris RMS with sirolimus-eluting PLLA coating and an equivalent 316L stainless steel stent with sirolimus-eluting PLLA coating. Six shunts (two shunt runs per pig) were run comparing the two scaffolds (n=9) in alternating order. Nested generalised linear mixed models were employed to compare variables between scaffold groups. Confocal fluorescent microscopy containing CD61/CD42b demonstrated that the 316L equivalent stent had significantly greater platelet coverage of the total scaffold compared with Magmaris (5.8% vs. 2.8%, adjusted rate ratio 2.21 [1.41, 3.47], p=0.012). Scanning electron microscopy demonstrated significantly greater thrombus deposition on the 316L equivalent stent as a percentage of the total scaffold compared with Magmaris (8.0% vs. 5.3%, p=0.009). Magmaris also had significantly less CD14 positive monocyte deposition and a trend towards less PM-1 positive neutrophil compared with the 316L equivalent stent.</p><p class="text-1er-paragraph"></p><p class="text-1er-paragraph"><span class="abstracts-titres">Conclusions:</span> Magmaris has less thrombogenicity and inflammatory cell deposition compared with the equivalent 316L stainless steel (in geometry and design) stent in a porcine arteriovenous shunt model. These data suggest that resorbable magnesium scaffolds may have inherent properties that reduce adhesion of platelets and inflammatory cells.</p> AU - Lipinski Michael J. AU - Acampado Eduardo AU - Cheng Qi AU - Adams Lila AU - Torii Sho AU - Gai Jiaxiang AU - Torguson Rebecca AU - Hellinga David G. AU - Joner Michael AU - Harder Claus AU - Zumstein Philine AU - Finn Aloke V. AU - Kolodgie D. Frank AU - Virmani Renu AU - Waksman Ron VL - 14 IS - 13 Y1 - 18/01/2019 Y1 - 2019 DOI - 10.4244/EIJ-D-17-00958 SP - 1420 EP - 1427 KW - bioresorbable scaffolds KW - clinical research PB - Europa Digital & Publishing SE - PERIPHERAL INTERVENTIONS UR - https://eurointervention.pcronline.com/article/comparison-of-acute-thrombogenicity-for-magnesium-versus-stainless-steel-stents-in-a-porcine-arteriovenous-shunt-model SN - 1774-024X ER -