TY - JOUR JO - EuroIntervention TI - Impact of mitral valve treatment choice on mortality according to aetiology AB - <p class="text-1er-paragraph"><span class="abstracts-titres">Aims:</span> Treatment strategies of high-risk patients with mitral regurgitation (MR) differ between disease based on functional and disease based on degenerative origin. In the present study, we aimed to evaluate the effect of surgical, percutaneous, or conservative treatment of MR according to MV mechanism, for high-risk patients.</p><p class="text-1er-paragraph"><span class="abstracts-titres">Methods and results:</span> Survival outcomes of MitraClip, surgical, or conservative strategies were compared for 688 high-risk patients with functional MR and 275 with degenerative MR. Cox regression and propensity analyses were used to correct for differences in baseline characteristics. For functional MR, conservative treatment proved to have a higher mortality hazard when compared to MitraClip treatment (hazard ratio [HR] 1.79, 95% confidence interval [CI]: 1.34 to 2.39, p&lt;0.001), while there was no significant difference in mortality hazard between MitraClip and surgery (HR 0.86, 95% CI: 0.54 to 1.38, p=0.541). For degenerative MR, no clear significant benefit was found when comparing MitraClip to conservative and surgical treatment.</p><p class="text-1er-paragraph"><span class="abstracts-titres">Conclusions:</span> High-risk patients with symptomatic functional MR have reduced mortality when undergoing MitraClip intervention, compared to those receiving conservative treatment.</p> AU - Kortlandt Friso AU - Velu Juliette AU - Schurer Remco AU - Van den Branden Ben J.L. AU - Bouma Berto AU - Kelder Johannes C. AU - Eefting Frank D. AU - Swaans Martin J. AU - Rensing Benno J.W.M. AU - Baan Jr Jan AU - Van Der Heyden Jan A.S. VL - 14 IS - 17 Y1 - 16/04/2019 Y1 - 2019 DOI - 10.4244/EIJ-D-18-00874 SP - 1733 EP - 1739 KW - clinical trial KW - death KW - mitral regurgitation KW - mitral valve repair PB - Europa Digital & Publishing SE - INTERVENTIONS FOR VALVULAR DISEASE AND HEART FAILURE UR - https://eurointervention.pcronline.com/article/impact-of-mitral-valve-treatment-choice-on-mortality-according-to-aetiology SN - 1774-024X ER -