TY - JOUR JO - EuroIntervention TI - Serial comparison of neointimal hyperplasia between the thin strut MiStent with microcrystalline sirolimus and the durable polymer coated everolimus-eluting Xience stent: 6- and 24-month results of DESSOLVE III OCT sub-study AB - <p class="ximage author-picture"><img class="Bloc-graphique-standard" src="https://files.eurointervention.com/issues/ahead_of_print/jaa.png" width="56" height="70" /></p> <p class="intertitre1"> </p> <p class="text-1er-paragraph"><span class="abstracts-titres">Aims:</span> DESSOLVE III OCT sub-study compared serially neointimal hyperplasia volume obstruction (%VO) between the thin strut MiStent with early polymer elimination and 9-month sustained drug release from microcrystalline sirolimus and the durable polymer coated everolimus-eluting Xience stent at 6 and 24 months after implantation.<br /><br /><span class="abstracts-titres">Methods and results: </span>The efficacy endpoint was %VO calculated as abluminal neointimal volume/stent volume. Thirty-six patients (MiStent 16 patients, 16 lesions, Xience 20 patients, 22 lesions) underwent serial OCT evaluation at both 6 and 24 months. At 6 months, mean abluminal %VO was significantly lower in the MiStent group than in Xience group (14.54&plusmn;3.70% vs. 19.11&plusmn;6.70%; p=0.011), whereas the difference in %VO between the two groups decreased at 24 months (20.88&plusmn;5.72% vs. 23.50&plusmn;7.33%; p=0.24). There was no significant difference in percentage malapposed struts and percentage uncovered struts between the two groups at both time points. <br /><br /><span class="abstracts-titres">Conclusions: </span>In the serial comparative OCT analysis of the MiStent vs. the Xience, the MiStent showed a more favourable efficacy for preventing neointimal formation with comparable strut tissue coverage, as compared with the Xience at 6 months, but this difference in %VO decreased at 24 months so that the difference in neointima at 24 months was no longer significant.</p> AU - Milewski Krzysztof AU - Takahashi Kuniaki AU - Asano Taku AU - Katagiri Yuki AU - Hochul Mariusz AU - Buszman P. Piotr AU - Tomaniak Mariusz AU - Gorycki B AU - Zurakowski Aleksander AU - Janas Adam AU - Mlodziankowski Adam AU - Kachel Mateusz AU - Wykrzykowska Joanna J. AU - Wijns William AU - de Winter J. Robbert AU - Buszman E. Pawel AU - Onuma Yoshinobu AU - Serruys Patrick W. VL - IS - Y1 - 07/05/2019 Y1 - 2019 DOI - 10.4244/EIJ-D-18-01201 SP - KW - clinical research KW - qca KW - optical coherence tomography PB - Europa Digital & Publishing UR - https://eurointervention.pcronline.com/article/serial-comparison-of-neointimal-hyperplasia-between-the-thin-strut-mistent-with-microcrystalline-sirolimus-and-the-durable-polymer-coated-everolimus-eluting-xience-stent-6-and-24-month-results-of-dessolve-iii-oct-sub-study SN - 1774-024X ER -