TY - JOUR JO - EuroIntervention TI - PROcedure related microvascular ACTIVation in long lEsions treated with bioresorbable vascular scaffold versus everolimus-eluting stent implantation (PROACTIVE trial) AB - <p class="text-1er-paragraph"><span class="abstracts-titres">Aims:</span> Significant platelet activation after long stented coronary segments has been associated with peri-procedural microvascular impairment and myonecrosis. In long lesions treated either with everolimus-eluting bioresorbable vascular scaffold (BVS) or everolimus-eluting stent (EES), we investigated (a) procedure-related microvascular impairment, and (b) relationship of platelet activation with microvascular function and related myonecrosis. <br/><br/><span class="abstracts-titres">Methods and results:</span> Patients (n=66) undergoing elective percutaneous coronary intervention (PCI) in long lesions were randomized 1:1 either to BVS or EES. Primary endpoint was the difference between groups in changes of pressure-derived corrected index of microvascular resistance (cIMR) after PCI. Peri-procedural myonecrosis was assessed by high sensitivity-cardiac troponin T (hs-cTnT), platelet reactivity by high-sensitivity adenosine diphosphate (hs-ADP)-induced platelet reactivity with the Multiplate Analyzer™. Post-dilatation was more frequent in the BVS group, with consequent longer procedure time. A significant difference was observed between the two groups in the primary endpoint of Δ cIMR (p= 0,04). Hs-ADP was not different between the 2 groups at different time points. Hs-cTnT significantly increased after PCI, without difference between the groups. <br/><br/><span class="abstracts-titres">Conclusions:</span> In long lesions, BVS implantation is associated with significant acute reduction in IMR as compared with EES, with no significant interaction with platelet reactivity or peri-procedural myonecrosis.</p> AU - Pellicano Mariano AU - Di Gioia Giuseppe AU - Ciccarelli Giovanni AU - Xaplanteris Panagiotis AU - Delrue Leen AU - Toth Gabor G. AU - Van Durme F AU - Heyse Alex AU - Wyffels Eric AU - Vanderheyden Marc AU - Bartunek Jozef AU - De Bruyne Bernard AU - Barbato Emanuele VL - IS - Y1 - 14/05/2019 Y1 - 2019 DOI - 10.4244/EIJ-D-18-01138 SP - KW - stable angina KW - bioresorbable scaffolds KW - clinical research KW - fractional flow reserve KW - other technique PB - Europa Digital & Publishing UR - https://eurointervention.pcronline.com/article/procedure-related-microvascular-activation-in-long-lesions-treated-with-bioresorbable-vascular-scaffold-versus-everolimus-eluting-stent-implantation-proactive-trial SN - 1774-024X ER -