TY - JOUR JO - EuroIntervention TI - Quantitative aortography for assessing aortic regurgitation after transcatheter aortic valve implantation: results of the multicentre ASSESS-REGURGE Registry AB - <div class="article__abstract"><p class="intertitre1">Abstract</p><p><b>Aims:</b> Quantitative aortography using videodensitometry is a valuable tool for quantifying paravalvular regurgitation after TAVI, especially in the minimalist approach &ndash; without general anaesthesia. However, retrospective assessment of aortograms showed moderate feasibility of assessment. We sought to determine the prospective feasibility of quantitative aortography after a protocol of acquisition.</p> <p><b>Methods and results:</b> This was a multicentre registry in Japan, Canada, the Netherlands and Germany including consecutive patients with Heart Team indication to undergo TAVI over a median period of 12 months. Operators performed final aortograms according to a pre-planned projection (either by CT or visually &ndash; Teng&rsquo;s rule). An independent core laboratory (Cardialysis) analysed all images for feasibility and for regurgitation assessment. From the four centres included in the present analysis, a total of 354 patients underwent TAVI following the acquisition protocol and all the aortograms were analysed by the core lab. The analyses were feasible in 95.5% (95% confidence interval [CI]: 93.2% to 97.5%) of the cases. This rate of analysable assessment was significantly higher than the feasibility in previous validation studies, such as in the RESPOND population (95.5% vs. 57.5%, p&lt;0.0001). No differences were observed among different planning strategies (CT 96.5% vs. Teng&rsquo;s rule 93%, p=0.159; or Circle 98.5% vs. 3mensio 95.8% vs. Teng&rsquo;s rule 93%, p=0.247).</p> <p><b>Conclusions:</b> ASSESS-REGURGE showed a high feasibility of assessment of regurgitation with quantitative aortography with protocoled acquisition. This may be of great importance for quantifying regurgitation in TAVI procedures (optimisation, guidance of post-dilatation), and in future clinical trials, in order to address sealing features of novel devices for TAVI objectively. ClinicalTrials.gov Identifier: NCT03644784</p></div> AU - Modolo Rodrigo AU - Chang Chin Chun AU - Tateishi Hiroki AU - Miyazaki Yosuke AU - Pighi Michele AU - Abdelghani Mohammad AU - Roos A. Martin AU - Wolff Quinten AU - Wykrzykowska Joanna J. AU - de Winter J. Robbert AU - Piazza Nicolo AU - Richardt Gert AU - Abdel-Wahab Mohamed AU - Soliman I.I. Osama AU - Onuma Yoshinobu AU - Van Mieghem Nicolas M. AU - Serruys Patrick W. VL - IS - Y1 - 23/05/2019 Y1 - 2019 DOI - 10.4244/EIJ-D-19-00362 SP - EP - KW - aortic regurgitation KW - paravalvular leak KW - tavi PB - Europa Digital & Publishing UR - https://eurointervention.pcronline.com/article/quantitative-aortography-for-assessing-aortic-regurgitation-after-transcatheter-aortic-valve-implantation-results-of-the-multicentre-assess-regurge-registry SN - 1774-024X ER -