TY - JOUR JO - EuroIntervention TI - Leaflet edge-to-edge treatment versus direct annuloplasty in patients for functional mitral regurgitation AB - <span class="abstracts-titres">Aims:</span>Interventional mitral repair techniques have evolved as safe and effective treatment options for patients with functional mitral regurgitation (FMR) at high or prohibitive surgical risk. Of the techniques available, the MitraClip device and Cardioband mitral repair system have been used most commonly. However, a direct comparison of the two devices, examining their effectiveness at reducing MR, reducing symptoms, and extending life expectancy, has not yet been performed. <br /><br /><span class="abstracts-titres">Methods and results:</span>We collected 123 consecutive patients that were treated with the Cardioband device and 455 consecutive patients treated with the MitraClip from five experienced European centers. Propensity score matching was performed, resulting in two groups with 93 patients each &ndash; with no significant differences regarding baseline demographic parameters &ndash; who underwent standardized 2D transthoracic echocardiography with assessment at baseline and clinical follow-up at 12 months. The success rate, defined as a reduction of MR to grade 2 or lower, was high in both groups (MR &le;2: MitraClip: 86%, Cardioband: 77%, p=0.18). The Cardioband was better at reducing heart failure symptoms (NYHA &le;2; 88%) than the MitraClip (75%) procedure (p=0.046) at 12-months follow-up. All-cause rehospitalization and mortality within 12 months were lower in Cardioband patients (mortality: OR 0.30, CI 0.09-0.98, p=0.032; rehospitalization: OR 0.57, CI: 0.28-0.97, p= 0.03). <br /><br /><span class="abstracts-titres">Conclusions:</span>The MitraClip and the Cardioband procedures effectively reduce MR and heart failure symptoms. However, patients undergoing the Cardioband procedure showed a more pronounced improvement with regard to functional NYHA class, rehospitalization, and mortality, compared to patients undergoing the MitraClip procedure. AU - Weber Marcel AU - Öztürk Can AU - Taramasso Maurizio AU - Pozzoli Alberto AU - Pfister Roman AU - Wösten Monique AU - Alessandrini Hannes AU - Latib Azeem AU - Denti Paolo AU - Kuck Karl-Heinz AU - Maisano Francesco AU - Baldus Stephan AU - Nickenig Georg VL - IS - Y1 - 21/05/2019 Y1 - 2019 DOI - 10.4244/EIJ-D-19-00468 SP - KW - depressed left ventricular function KW - mitral regurgitation KW - mitral valve repair PB - Europa Digital & Publishing UR - https://eurointervention.pcronline.com/article/leaflet-edge-to-edge-treatment-versus-direct-annuloplasty-in-patients-for-functional-mitral-regurgitation SN - 1774-024X ER -