TY - JOUR JO - EuroIntervention TI - Usefulness of mean pulmonary artery pressure for predicting outcomes of transcatheter closure of atrial septal defect with pulmonary arterial hypertension AB - <span class="abstracts-titres">Aims:</span>This study aimed to provide a simple index for predicting the definite indication&nbsp;for transcatheter closure&nbsp;of atrial septal defect (ASD) with&nbsp;pulmonary arterial hypertension(PAH)<br /><br /><span class="abstracts-titres">Methods and results:</span>A positive responseafter attempted occlusion was defined as mean pulmonary artery pressure (MPAP) &le; 30 mmHg or the decrement percentage of it &ge;20% compared with the baseline. If a positive response was achieved, the occluder would be released, and the procedure was defined as successful. In 209 patients underwent successful procedure without PAH-specific medicine, there was a dramatic decrease in the percentage of patients with pulmonary arterial systolic pressure (PASP) &ge; 50 mmHg from baseline to the one-year follow-up (79.4% to 14.0%, P&lt;0.001). The optimalcut-offvalue of MPAP to predict a positive response without PAH-specific medicine was 35.0 mmHg, with an area under the curve (AUC) of 0.919 (P &lt;0.001). Administration of inhaled iloprost extended the cut-off point to 50.0 mmHg to reach a positive response, with an AUC of 0.774 (P=0.003).&nbsp;<br /><br /><span class="abstracts-titres">Conclusions:</span>&nbsp;This large-scale studyindicated that MPAP could be a simple but powerful index to predict benefit from closure in adult ASD patients with PAH. AU - Pan Wenzhi AU - Zhang Yuan AU - Guan Lihua AU - Zhang Xiaochun AU - Zhang Lei AU - Yang Lifan AU - Ge Junbo AU - Zhou Daxin VL - IS - Y1 - 18/06/2019 Y1 - 2019 DOI - 10.4244/EIJ-D-19-00172 SP - KW - atrial septal defect KW - pulmonary hypertension KW - clinical research PB - Europa Digital & Publishing UR - https://eurointervention.pcronline.com/article/usefulness-of-mean-pulmonary-artery-pressure-for-predicting-outcomes-of-transcatheter-closure-of-atrial-septal-defect-with-pulmonary-arterial-hypertension SN - 1774-024X ER -