TY - JOUR JO - EuroIntervention TI - Derivation and external validation of a novel risk score for prediction of 30-day mortality after percutaneous coronary intervention AB - <p><strong>Aims:</strong> Early mortality after percutaneous coronary intervention (PCI) is relatively rare. Current risk prediction models for this event are outdated. We sought to derive a 30-day mortality risk score after PCI.</p> <p><strong>Methods and results:</strong> The score was derived from a pooled database of 21 randomised clinical trials using a logistic regression model incorporating clinical and angiographic variables. The score was validated in a separate unrestricted study population, the Assessment of Dual AntiPlatelet Therapy With Drug Eluting Stents (ADAPT-DES) registry. Of 32,882 eligible patients, 75% had data for all 19 variables used for score derivation. The independent predictors of 30-day mortality were age, presentation with ACS, diabetes mellitus, use of first-generation drug-eluting stents, left main or left anterior descending artery lesion, prior myocardial infarction (MI), and suboptimal flow in the artery before or after PCI. The median [interquartile range] score in the derivation cohort was 5 [3, 6] and overall mortality was 0.49%, ranging from 0.08% to 1.64% with scores of 0-16. The 30-day mortality rate was approximately tenfold higher in patients with a score at or above versus below the median of 5 (0.86% versus 0.08%, p&lt;0.0001). Discrimination in both cohorts was very good (C statistic=0.848 and 0.828, respectively), and calibration was satisfactory.</p> <p><strong>Conclusions:</strong> A novel risk score incorporating eight readily available clinical and angiographic variables had high discrimination for 30-day death after PCI across a wide range of clinical scenarios.</p> AU - Brener J. Sorin AU - Leon Martin B. AU - Serruys Patrick W. AU - Smits Pieter C. AU - von Birgelen Clemens AU - Mehran Roxana AU - Kirtane Ajay J. AU - Witzenbichler Bernhard AU - Rinaldi Michael J. AU - Metzger D. Christopher AU - Mazzaferri L. Ernest AU - Zhang Zixuan AU - Stone W. Gregg VL - 15 IS - 6 Y1 - 09/08/2019 Y1 - 2019 DOI - 10.4244/EIJ-D-19-00262 SP - e551 EP - e557 KW - death KW - drug-eluting stent KW - risk stratification PB - Europa Digital & Publishing SE - Coronary interventions UR - https://eurointervention.pcronline.com/article/derivation-and-external-validation-of-a-novel-risk-score-for-prediction-of-30-day-mortality-after-percutaneous-coronary-intervention SN - 1774-024X ER -