TY - JOUR JO - EuroIntervention TI - Final results of the Randomised Evaluation of short-term DUal antiplatelet therapy in patients with acute Coronary syndromE treated with a new generation stent (REDUCE) trial AB - <span class="abstracts-titres">Aims:</span>. The optimal duration of DAPT in ACS patients treated with DES is still unclear.&nbsp;<br /><br /><span class="abstracts-titres">Methods and results:</span>. REDUCE is a prospective, open label, multicenter, investigator-initiated study that randomised 1496 ACS patients after treatment with COMBO to either 3 (n=751) or 12-month (n=745) of DAPT. Primary study endpoint was a composite of all cause mortality, myocardial infarction, stent thrombosis, stroke, target-vessel revascularisation and bleeding at 12 months. No difference was observed in demographic and clinical characteristics between the two groups, except for gender (p=0.01). At 1 year follow-up non-inferiority of 3 vs 12-month DAPT in the primary endpoint was met (8.2%vs8.4%,pnon-inferiority&lt;0.001). The similar outcome between the two groups was confirmed at 2-year follow-up (11.6%vs12.1%,p=0.76), with no significant difference in overall mortality (3.1%vs2.2%,p=0.27), cardiac mortality (1.8%vs1.1%,p=0.28), stent thrombosis (1.6% vs0.8%,p=0.16) and major bleeding (3.3% vs4.0%,p=0.46).&nbsp;<br /><br /><span class="abstracts-titres">Conclusions:</span>. The results show that among ACS patients treated with COMBO, 3 months is non-inferior to 12 months DAPT. However, given the numerically higher rates of mortality and ST in the 3 months DAPT group, 1-year DAPT should still be recommended in ACS until more information becomes available. A 3 months DAPT strategy should be considered only if clinically mandated. AU - De Luca Giuseppe AU - Damen A. Sander AU - Camaro Cyril AU - Benit Edouard AU - Verdoia Monica AU - Rasoul Saman AU - Liew Bang Houng AU - Polad Jawed AU - Azman Ahmad Wan AU - Zambahari Robaayah AU - Postma Sonja AU - Kedhi Elvin AU - Suryapranata Harry AU - Barbieri Lucia AU - Lee Stephen W. AU - Lalmand Jacques AU - van der Schaaf J. René AU - Koh Tian H. AU - Timmermans Sr. Philippe AU - Dilling-Boer Dagmara AU - Veenstra Leo AU - van 't Hof Arnoud W.J. AU - Roolvink Vincent AU - Kolkman Evelien AU - Brouwer Marc A. VL - IS - Y1 - 20/08/2019 Y1 - 2019 DOI - 10.4244/EIJ-D-19-00539 SP - KW - acs / nste-acs KW - stemi KW - drug-eluting stent PB - Europa Digital & Publishing UR - https://eurointervention.pcronline.com/article/final-results-of-the-randomised-evaluation-of-short-term-dual-antiplatelet-therapy-in-patients-with-acute-coronary-syndrome-treated-with-anew-generation-stent-reduce-trial SN - 1774-024X ER -