TY - JOUR JO - EuroIntervention TI - Mid-term Procedural and Clinical Outcomes of Percutaneous Paravalvular Leak Closure With the Occlutech Paravalvular Leak Device AB - <span class="abstracts-titres">Aims:</span> To assess the efficacy and safety of the Occlutech Paravalvular Leak Device (PLD) for the percutaneous closure of paravalvular leaks (PVL).&nbsp;<br /><br /><span class="abstracts-titres">Methods and results:</span> Patients with PVL were enrolled at 21 sites from 9 countries. Indications for PVL closure were heart failure and/or hemolytic anemia. Endpoint measures were changes in PV regurgitation grade, NYHA class and requirement for hemolysis-related transfusion. One-hundred thirty-six patients with mitral (67.6%) or aortic (32.4%) leaks were included (mean age 66.7 years, 58% men). Thirty-one percent had multiple PVLs. The proportion of patients with NYHA III/IV decreased from 77.3% at baseline to 16.9% at latest follow-up. The proportion of patients with need for hemolysis-related blood transfusion decreased from 36.8% to 5.9% and 8.3% to 0% for ML patients and AL patients, respectively. All cause mortality was 7.4%. Complications included interference with valve leaflets (0.7%), transient device embolization (percutaneously solved) (0.7%), late device embolization (0.7%), recurrent hemolytic anemia (2.2%), new onset hemolytic anemia (0.7%), valve surgery (2.2%), need for repeat closure (0.7%), complications at femoral puncture site (0.7%) and arrythmias requiring treatment (4.4%).&nbsp;<br /><br /><span class="abstracts-titres">Conclusions:</span> PVL closure with the Occlutech PLD demonstrated high success rate associated with significant clinical improvement and a relatively low rate of serious complications. AU - Onorato Eustaquio Maria AU - Muratori Manuela AU - Smolka Grzegorz AU - Zorinas Aleksejus AU - Zakarkaite Diana AU - Christos P. Christous AU - Mussayev Abdurashid AU - Bauer Fabrice AU - Gandet Thomas AU - Martinelli Luca Gian AU - Costante Maria Anna AU - Bartorelli Antonio L VL - IS - Y1 - 20/08/2019 Y1 - 2019 DOI - 10.4244/EIJ-D-19-00517 SP - KW - imaging modalities KW - specific closure device / technique KW - transesophageal echocardiogram KW - transthoracic echocardiogram PB - Europa Digital & Publishing UR - https://eurointervention.pcronline.com/article/mid-term-procedural-and-clinical-outcomes-of-percutaneous-paravalvular-leak-closure-with-the-occlutech-paravalvular-leak-device SN - 1774-024X ER -