TY - JOUR JO - EuroIntervention TI - Influence of target vessel on prognostic relevance of fractional flow reserve after coronary stenting AB - <p class="text-1er-paragraph"><strong><span class="abstracts-titres"><span class="appel-table-et-figure">Aims:</span></span></strong> We sought to investigate the influence of the target vessel on the prognostic relevance of fractional flow reserve (FFR) after percutaneous coronary intervention (PCI).</p> <p class="text-1er-paragraph"><strong><span class="abstracts-titres">Methods and results:</span></strong> A total of 835 patients with available FFR after second-generation drug-eluting stent (DES) implantation were included in this study. The primary outcome was target-vessel failure (TVF), including cardiac death, target vessel-related myocardial infarction, and clinically driven target vessel revascularisation. The target vessel was the left anterior descending artery (LAD) in 603 patients (72.2%) and non-LAD in 232 patients (27.8%). The distribution pattern of post-PCI FFR values was different between the LAD and non-LAD (p&lt;0.001). The optimal cut-off values of post-PCI FFR for predicting TVF were 0.82 and 0.88 in the LAD and non-LAD, respectively. The cumulative incidence of TVF was significantly higher in patients with lower post-PCI FFR than each cut-off value (10.9% vs. 2.5%, hazard ratio [HR] 4.08, 95% confidence interval [CI]: 2.63-6.34, p&lt;0.001 in LAD; 8.0% vs. 1.9%, HR 6.00, 95% CI: 1.78-20.26, p=0.004 in non-LAD).</p> <p class="text-1er-paragraph"><strong><span class="abstracts-titres">Conclusions:</span></strong> Higher post-PCI FFR after second-generation DES implantation was associated with better clinical outcomes. Different cut-off values of post-PCI FFR need to be applied according to the target vessel.&nbsp;ClinicalTrials Identifier: NCT01873560</p> AU - Hwang Doyeon AU - Lee Joo Myung AU - Lee Hyun-Jong AU - Kim Hong Su AU - Nam Chang-Wook AU - Hahn Joo-Yong AU - Shin Eun-Seok AU - Matsuo Akiko AU - Tanaka Nobuhiro AU - Matsuo Hitoshi AU - Lee Yun Sung AU - Doh Joon-Hyung AU - Koo Bon-Kwon VL - 15 IS - 5 Y1 - 29/08/2019 Y1 - 2019 DOI - 10.4244/EIJ-D-18-00913 SP - 457 EP - 464 KW - clinical research KW - drug-eluting stent KW - fractional flow reserve PB - Europa Digital & Publishing SE - Coronary interventions UR - https://eurointervention.pcronline.com/article/influence-of-target-vessel-on-prognostic-relevance-of-fractional-flow-reserve-after-coronary-stenting SN - 1774-024X ER -