TY - JOUR JO - EuroIntervention TI - Fractional Flow Reserve Guided PCI in Patients With and Without Left Ventricular Hypertrophy: a DANAMI-3-PRIMULTI Sub-study AB - <span class="abstracts-titres">Aims:</span> To investigate the correlation between fractional flow reserve (FFR) and diameter stenosis in patients with STEMI with and without left ventricular hypertrophy (LVH), and the influence of LVH on complete FFR-guided revascularization versus culprit only, in terms of risk of clinical outcome.&nbsp;<br /><br /><span class="abstracts-titres">Methods and results:</span> In this DANAMI-3-PRIMULTI sub-study, 279 patients with STEMI had cardiac magnetic resonance (CMR) for assessment of left-ventricular-mass-index. Ninety-six patients had FFR evaluation of a non-culprit lesion. Diameter stenosis of the non-culprit lesion was determined with 2-dimensional quantitative-coronary-analysis. The diameter stenosis (56.9% vs. 54.3%, p=0.38) and FFR value (0.83 vs. 0.85, p=0.34) were significantly correlated in both groups (Spearmans &rho;=-0.40 and -0.41 without LVH and with LVH, respectively; p&lt;0.001) but was not different between patients without and with LVH (p for interaction =0.87). FFR-guided complete revascularization was associated with reduced risk of death, myocardial infarction or ischemia-driven revascularization for both patients without LVH (HR 0.42, 95%CI 0.20-0.85) and for patients with LVH (HR 0.50, 95%CI 0.17-0.47), with no interaction between the FFR-guided complete revascularization and LVH (p for interaction =0.82).&nbsp;<br /><br /><span class="abstracts-titres">Conclusions:</span> LVH did not interact with the correlation between diameter stenosis and FFR and did not modify the impact of complete revascularization on the occurrence of subsequent clinical events. AU - Sabbah Muhammad AU - Nepper-Christensen Lars AU - Lønborg Jacob AU - Helqvist Steffen AU - Køber Lars AU - Høfsten Eik Dan AU - Ahtarovski Kiril Aleksov AU - Göransson Christoffer AU - Kyhl Kasper AU - Schoos Malby Mikkel AU - Vejlstrup Niels AU - Kelbæk Henning AU - Engstrøm Thomas VL - IS - Y1 - 20/11/2019 Y1 - 2019 DOI - 10.4244/EIJ-D-19-00577 SP - KW - stemi KW - multiple vessel disease KW - fractional flow reserve PB - Europa Digital & Publishing UR - https://eurointervention.pcronline.com/article/fractional-flow-reserve-guided-pci-in-patients-with-and-without-left-ventricular-hypertrophy-a-danami-3-primulti-sub-study SN - 1774-024X ER -