TY - JOUR JO - EuroIntervention TI - Multivessel percutaneous coronary intervention in patients with acute myocardial infarction and severe renal dysfunction AB - <p><strong>Aims:</strong> The aim of this study was to compare the outcomes between multivessel and infarct-related artery (IRA)-only percutaneous coronary intervention (PCI) in patients with acute myocardial infarction (AMI), multivessel disease (MVD), and severe renal dysfunction (RD) using the nationwide AMI registry.</p> <p><strong>Methods and results:</strong> Among 13,104 patients, 537 diagnosed with AMI and MVD who had severe RD at presentation (estimated glomerular filtration rate [GFR] &lt;30 mL/min/1.73 m<sup>2</sup>, mean: 19.1&plusmn;7.5 mL/min/1.73&nbsp;m<sup>2</sup>) and underwent PCI during index hospitalisation were selected. The patients were classified according to treatment strategy, i.e., multivessel PCI (49.0%) or IRA-only PCI. The primary endpoint was major adverse cardiac events (MACE), a composite of all-cause death, myocardial reinfarction, re-hospitalisation for heart failure, and any repeat revascularisation at one year. The safety outcome was the worsening of renal function (WRF), defined as a 30% reduction in estimated GFR from baseline to 12-month follow-up. The adjusted MACE risks were similar in groups after Cox regression (41.8% vs 39.8%, hazard ratio [HR] 1.008 [0.743-1.367]) and propensity score-matching analysis (HR 0.974 [0.651-1.377]). Multivessel PCI showed a significant tendency of higher rates of WRF (24.8% vs 11.1%, adjusted odds ratio 2.134 [0.976-4.668]).</p> <p><strong>Conclusions:</strong> Multivessel PCI was associated with similar outcomes compared to IRA-only PCI in patients with AMI, MVD, and severe RD.</p> AU - Song Sang Pil AU - Hahn Joo-Yong AU - Gwon Hyeon-Cheol AU - Jeon Ki-Hyun AU - Yu Woong Cheol AU - Rha Seung-Woon AU - Yoon Chang-Hwan AU - Jeong Myung Ho VL - 15 IS - 11 Y1 - 06/12/2019 Y1 - 2019 DOI - 10.4244/EIJ-D-19-00034 SP - e1014 EP - e1021 KW - multiple vessel disease KW - non-stemi KW - renal insufficiency KW - stemi PB - Europa Digital & Publishing SE - Coronary interventions UR - https://eurointervention.pcronline.com/article/multivessel-percutaneous-coronary-intervention-in-patients-with-acute-myocardial-infarction-and-severe-renal-dysfunction SN - 1774-024X ER -