TY - JOUR JO - EuroIntervention TI - Stroke after MitraClip:Systematic Review and Meta-Analysis AB - <span class="abstracts-titres">Aims:</span> To assess stroke rate after transcatheter mitral valve repair (TMVR) with MitraClip, comparing it with surgical mitral valve repair (SMVR) and optimal medical treatment (OMT).&nbsp;<br /><br /><span class="abstracts-titres">Methods and results:</span> We systematically searched PubMed, Embase and Cochrane Controlled Register of Trials, in December 2018, for studies comparing TMVR with SMVR and/or OMT for the treatment of severe mitral regurgitation. Random‐effects and cumulative meta-analysis was performed. Ten studies were included: seven of TMVR versus SMVR and three of TMVR versus OMT, providing a total of 1881 patients and 61 pooled strokes (16 in TMVR versus SMVR and 45 in TMVR versus OMT). There was no difference in stroke incidence between TMVR and SMVR (pooled OR 0.49 [0.17, 1.42], P=0.19). Cumulative meta-analysis showed a significantly lower stroke rate in TMVR, compared to SMVR (OR 0.4 [0.24, 0.67], P&lt; 0.01). For TMVR versus OMT, no difference in stroke rate was identified (pooled OR 1.09 [0.60, 1.97], P=0.79). Post-procedure de novo atrial fibrillation was more frequent in SMVR when compared with TMVR.&nbsp;<br /><br /><span class="abstracts-titres">Conclusions:</span>Although with a low number of pooled events, there was a trend for a lower post-procedure stroke in TMVR when compared with SMVR and a similar one between TMVR and OMT alone. AU - Barros da Silva Patricia AU - Sousa P. José AU - Oliveiros Bárbara AU - Donato Helena AU - Costa Marco A. AU - Gonçalves Lino AU - Teixeira Rogério VL - IS - Y1 - 10/12/2019 Y1 - 2019 DOI - 10.4244/EIJ-D-19-00602 SP - KW - atrial fibrillation KW - mitral valve repair KW - stroke KW - Anticoagulant therapy PB - Europa Digital & Publishing UR - https://eurointervention.pcronline.com/article/stroke-after-mitraclipsystematic-review-and-meta-analysis SN - 1774-024X ER -