TY - JOUR JO - EuroIntervention TI - Transcatheter aortic valve implantation improves cognitive function associated with increased cerebral blood flow in elderly patients with severe aortic stenosis AB - <span class="abstracts-titres">Aims:</span> The aim of this study was to examine the mechanisms of cognitive impairment and reversibility in elderly patients with severe aortic stenosis (AS) after transcatheter aortic valve implantation (TAVI) with a special reference to cerebral blood flow (CBF).&nbsp;<br /><br /><span class="abstracts-titres">Methods and results:</span> We examined 15 elderly patients with severe AS (mean age 83.2&plusmn;4.5 years, 12 female) who underwent TAVI.&nbsp; Before and 3 months after TAVI, we evaluated cognitive function with the Logical Memory II (LM II), cardiac output (CO) with echocardiography, and CBF with 99mTc single-photon emission computed tomography (SPECT).&nbsp; LM II score and CO were significantly increased after TAVI compared with baseline (P&lt;0.01 for LM II, P&lt;0.005 for CO). &nbsp;Notably, CBF in the local regions, including that in the right hippocampus, was significantly increased after TAVI (P&lt;0.005 at each voxel).&nbsp; The patients with increased CO after TAVI also showed significantly increased CBF in the right hippocampus compared with those without it (P&lt;0.01).&nbsp; Importantly, CBF in the right hippocampus were positively correlated with LM II scores (P&lt;0.05).<br /><br /><span class="abstracts-titres">Conclusions:</span> These results provide the first evidence that TAVI may improve cognitive functions associated with increased cerebral perfusion especially in the hippocampus in elderly patients with severe AS. AU - Tsuchiya Satoshi AU - Matsumoto Yasuharu AU - Suzuki Hideaki AU - Takanami Kentaro AU - Kikuchi Yoku AU - Takahashi Jun AU - Miyata Satoshi AU - Tomita Naoki AU - Kumagai Kiichiro AU - Taki Yasuyuki AU - Saiki Yoshikatsu AU - Arai Hiroyuki AU - Shimokawa Hiroaki VL - IS - Y1 - 21/01/2020 Y1 - 2020 DOI - 10.4244/EIJ-D-19-00489 SP - KW - aortic stenosis KW - tavi KW - chronic heart failure PB - Europa Digital & Publishing UR - https://eurointervention.pcronline.com/article/transcatheter-aortic-valve-implantation-improves-cognitive-function-associated-with-increased-cerebral-blood-flow-in-elderly-patients-with-severe-aortic-stenosis SN - 1774-024X ER -