TY - JOUR JO - EuroIntervention TI - Impact of aetiology of mitral regurgitation on outcome after Mitraclip: lessons learned from MitraSwiss Registry. AB - <p><strong>Aims:</strong> The Swiss national registry on percutaneous mitral valve interventions was established in 2011 to monitor safety/ efficacy of percutaneous mitral valve repair (PMVR) with MitraClip. We report in-hospital, short and mid-term outcomes of all patients prospectively enrolled.</p> <p><strong>Methods and results: </strong>&nbsp;Since 2011, MitraSwiss enrolled 1212 patients with moderate and severe MR of functional (FMR) or degenerative (DMR) etiology treated with PMVR in 10 centers. Pre-specified endpoints included clinical, echocardiographic and functional parameters with follow up planned up to 5 years. Outcomes are compared according to MR etiology. Acute procedural success was achieved in 91.5% of cases, with no differences between FMR and DMR and sustained good mid-term results. NYHA class and pulmonary pressure improved significantly in both cohorts. Cumulative probability of death at 5 years was 54% (95%CI 45-63) in FMR and 45% (95%CI 37-54) in the DMR&nbsp; (HR=1.15, p=0.009). Age, anemia, impaired renal function and reduced left ventricular ejection fraction resulted as independent predictors of death at 5 years.</p> <p><strong>Conclusion</strong><strong>s:</strong> In a large contemporary cohort of non-surgical patients with severe MR, PMVR confirms its safety and effectiveness. At a mid-term follow up mortality and MACE are lower in DMR patients, though MR aetiology is not directly and independently associated with outcome.</p> AU - Sürder Daniel AU - Klersy Catherine AU - Corti Roberto AU - Biasco Luigi AU - Gaemperli Oliver AU - Maisano Francesco AU - Toggweiler Stefan AU - Jeger Raban V. AU - Naegeli Barbara AU - Noble Stéphane AU - Biaggi Patric AU - Moccetti Tiziano AU - Pedrazzini Giovanni AU - Curti Moreno AU - Moarof Igal AU - Muller Olivier VL - IS - Y1 - 04/02/2020 Y1 - 2020 DOI - 10.4244/EIJ-D-19-00718 SP - KW - mitral regurgitation KW - mitral valve repair KW - chronic heart failure PB - Europa Digital & Publishing UR - https://eurointervention.pcronline.com/article/impact-of-aetiology-of-mitral-regurgitation-on-outcome-after-mitraclip-lessons-learned-from-mitraswiss-registry SN - 1774-024X ER -