TY - JOUR JO - EuroIntervention TI - Review and meta-analysis of renal artery damage following percutaneous renal denervation with radiofrequency renal artery ablation AB - <p><strong>Aims:</strong> We aimed to estimate the rate of renal artery adverse events following renal denervation with the most commonly applied radiofrequency catheter system based on a comprehensive review of published reports.</p> <p><strong>Methods and results:</strong> We reviewed 50 published renal denervation (RDN) trials reporting on procedural safety including 5,769 subjects with 10,249 patient-years of follow-up. Twenty-six patients with renal artery stenosis or dissection (0.45%) were identified of whom 24 (0.41%) required renal artery stenting. The primary meta-analysis of all reports indicated a 0.20% pooled annual incidence rate of stent implantation (95% CI: 0.12 to 0.29% per year). Additional sensitivity analyses yielded consistent pooled estimates (range: 0.17 to 0.42% per year). Median time from RDN procedure to all renal intervention was 5.5 months (range: 0 to 33 months); 79% of all events occurred within one year of the procedure. A separate review of 14 clinical trials reporting on prospective follow-up imaging using either magnetic resonance imaging, computed tomography or angiography following RDN in 511 total subjects identified just 1 new significant stenosis (0.20%) after a median of 11 months post procedure (one to 36 months).</p> <p><strong>Conclusions:</strong> Renal artery reintervention following renal denervation with the most commonly applied RF renal denervation system (Symplicity) is rare. Most events were identified within one year.</p> AU - Townsend R. Raymond AU - Walton S. Antony AU - Hettrick A. Douglas AU - Hickey L. Graeme AU - Weil Joachim AU - Sharp Andrew S.P. AU - Blankestijn J. Peter AU - Böhm Michael AU - Mancia Giuseppe VL - 16 IS - 1 Y1 - 20/05/2020 Y1 - 2020 DOI - 10.4244/EIJ-D-19-00902 SP - 89 EP - 96 KW - clinical research KW - renal sympathetic denervation KW - uncontrolled hypertension PB - Europa Digital & Publishing SE - Interventions for hypertension and stroke UR - https://eurointervention.pcronline.com/article/incidence-of-renal-artery-damage-following-percutaneous-renal-denervation-with-radio-frequency-renal-artery-ablation-systems-review-and-meta-analysis-of-published-reports SN - 1774-024X ER -