TY - JOUR JO - EuroIntervention TI - Impact of right ventricular volumes on the outcomes of TAVR: a volumetric analysis of preprocedural computed tomography AB - <p><strong>Aims:</strong> The aim of this study was to assess the prognostic implications of increased right ventricle volume index (RVVI) using cardiac-gated computed tomography angiography (CCTA) data among patients undergoing transcatheter valve replacement (TAVR).</p> <p><strong>Methods and results:</strong> CCTA of 323 patients who underwent TAVR at Stanford University Medical Center (CA, USA) and Tel Aviv Medical Center (Israel) between 2013 and 2016 was analysed by an automatic four-chamber volumetric software and grouped into quartiles according to RVVI. Higher one-year mortality rates were noted for the upper quartiles &ndash; 5%, 4.9%, 8.6%, and 16% (p=0.039), in Q1 &lt;59 ml/m<sup>2</sup>, Q2 59-69 ml/m<sup>2</sup>, Q3 69-86 ml/m<sup>2</sup>, and Q4 &gt;86 ml/m<sup>2</sup>, respectively. However, the differences were not significant after propensity score adjustments. Sub-analyses of Q1 demonstrated an escalating risk for one-year mortality in concordance to RVVI: HR 2.28, HR 2.76, and HR 4.7, for the upper 25<sup>th</sup>, 15<sup>th</sup>, and 5<sup>th</sup> percentiles, respectively (p&lt;0.05 for all comparisons). After propensity score adjustments for clinical and echocardiographic characteristics, only the upper 5<sup>th</sup> percentiles (RVVI &gt;120 ml/m<sup>2</sup>) retained statistical significance (HR 2.82, 95% CI: 1.02-7.78, p=0.045). Notably, 68.7% of patients from this group were considered low-intermediate risk for surgery.</p> <p><strong>Conclusions:</strong> Cardiac volumetric data by CCTA performed for procedural planning may help to predict outcome in patients undergoing TAVR.</p> AU - Rozenbaum Zach AU - Maret Eva AU - Lax Lilian AU - Shmilovich Haim AU - Finkelstein Ariel AU - Steinvil Arie AU - Halkin Amir AU - Banai Shmuel AU - Cohen Dotan AU - Topilski Yan AU - Berliner Shlomo AU - Fleischmann Dominik AU - Aviram Galit VL - 16 IS - 2 Y1 - 12/06/2020 Y1 - 2020 DOI - 10.4244/EIJ-D-19-00651 SP - e121 EP - e128 KW - aortic stenosis KW - imaging modalities KW - tavr PB - Europa Digital & Publishing SE - Interventions for valvular disease and heart failure UR - https://eurointervention.pcronline.com/article/increased-mortality-among-patients-with-higher-right-ventricular-volumes-volumetric-analysis-of-pre-trans-catheter-aortic-valve-replacement-ct-angiography SN - 1774-024X ER -