TY - JOUR JO - EuroIntervention TI - Short-duration triple antithrombotic therapy for atrial fibrillation patients who require coronary stenting: results of the SAFE-A study AB - <p><strong>Aims:</strong> We aimed to determine whether shortening the duration of P2Y<sub>12</sub> inhibitor therapy can reduce the risk of bleeding without increasing the risk of major adverse cardiovascular events following coronary stenting in patients with atrial fibrillation (AF).</p> <p><strong>Methods and results:</strong> The SAFE-A is a randomised controlled trial that compared one-month and six-month P2Y<sub>12</sub> inhibitor therapy, in combination with aspirin and apixaban for patients with AF who require coronary stenting. The primary endpoint was the incidence of any bleeding events, defined as Thrombolysis In Myocardial Infarction major/minor bleeding, bleeding with various Bleeding Academic Research Consortium grades, or bleeding requiring blood transfusion within 12 months after stenting. The study aimed to enrol 600 patients but enrolment was slow. Enrolment was terminated prematurely after enrolling 210 patients (72.7&plusmn;8.2 years; 81% male). The incidence of the primary endpoint did not differ between the one-month and six-month groups (11.8% vs 16.0%; hazard ratio [HR] 0.70, 95% confidence interval [CI]: 0.33-1.47; p=0.35).</p> <p><strong>Conclusions:</strong> The study evaluated the safety of withdrawing the P2Y<sub>12</sub> inhibitor from triple antithrombotic prescription one month after coronary stenting. However, enrolment was prematurely terminated because it was slow. Therefore, statistical power was not sufficient to assess the differences in the primary endpoint.</p> AU - Hoshi Tomoya AU - Sato Akira AU - Hiraya Daigo AU - Watabe Hiroaki AU - Takeyasu Noriyuki AU - Nogami Akihiko AU - Ohigashi Tomohiro AU - Gosho Masahiko AU - Ieda Masaki AU - Aonuma Kazutaka VL - 16 IS - 2 Y1 - 12/06/2020 Y1 - 2020 DOI - 10.4244/EIJ-D-19-00920 SP - e164 EP - e172 KW - Anticoagulant therapy KW - atrial fibrillation KW - drug-eluting stent PB - Europa Digital & Publishing SE - Coronary interventions UR - https://eurointervention.pcronline.com/article/short-duration-triple-antithrombotic-therapy-for-atrial-fibrillation-patients-who-require-coronary-stenting-results-of-the-safe-a-study SN - 1774-024X ER -