TY - JOUR JO - EuroIntervention TI - Impact of coronary lesion complexity in percutaneous coronary intervention: one-year outcomes from the large, multicentre e-Ultimaster registry AB - <p><strong>Aims:</strong> The present study sought to examine the prevalence, clinical characteristics and one-year outcomes of patients undergoing percutaneous coronary intervention (PCI) to complex lesions (multivessel PCI, &ge;3 stents, &ge;3 lesions, bifurcation with &ge;2 stents, total stent length &gt;60 mm or chronic total occlusion [CTO]) in a prospective multicentre registry.</p> <p><strong>Methods and results:</strong> Using the e-Ultimaster multicentre registry, a post hoc subgroup analysis was performed on 35,839 patients undergoing PCI, stratified by procedure complexity, and further by number and type of complex features. Overall, complex PCI patients (n=9,793, 27.3%) were older, more comorbid and were associated with an increased hazard ratio (HR) of the composite endpoint at one year (target lesion failure [TLF]: 1.41 [1.25; 1.59]), driven by an increased hazard of cardiac death (1.28 [1.05; 1.55]), target vessel myocardial infarction (1.48 [1.18; 1.86]) and clinically driven target lesion revascularisation. The hazard of complications increased with the rising number of complex features (3-6 vs 1-2 vs none) for all outcomes. All individual complex features were associated with an increased hazard of composite complications (except CTO) and definite/probable stent thrombosis.</p> <p><strong>Conclusions:</strong> Overall, complex PCI is associated with an increased risk of mortality and complications at one year. The number and types of complex features have differing impacts on long-term outcomes.</p> AU - Mohamed O. Mohamed AU - Polad Jawed AU - Hildick-Smith David AU - Bizeau Olivier AU - Baisebenov K. Ruslan AU - Roffi Marco AU - Iñiguez Andrés AU - Chevalier Bernard AU - von Birgelen Clemens AU - Roguin Ariel AU - Aminian Adel AU - Angioi Michael AU - Mamas Mamas A. VL - IS - Y1 - 25/06/2020 Y1 - 2020 DOI - 10.4244/EIJ-D-20-00361 SP - KW - bifurcation KW - chronic coronary total occlusion KW - clinical research KW - drug-eluting stent KW - multiple vessel disease KW - risk stratification PB - Europa Digital & Publishing UR - https://eurointervention.pcronline.com/article/impact-of-coronary-lesion-complexity-in-percutaneous-coronary-intervention-one-year-outcomes-from-the-large-multicentre-e-ultimaster-registry SN - 1774-024X ER -