TY - JOUR JO - EuroIntervention TI - Transcatheter Reshaping of the Mitral Annulus in Patients with Functional Mitral Regurgitation: One-year Outcomes of the MAVERIC Trial AB - Aims To assess the one-year safety and efficacy of the transcatheter ARTO&trade; system in the treatment of functional mitral regurgitation (FMR).<br /><br />Methods and Results MAVERIC is a multicenter, prospective, non-randomized pre-commercial study. Eligible patients were on guideline-recommended therapy for NYHA class II-IV systolic heart failure and had an FMR grade&ge;2+. <br />ARTO&trade; system was implanted in forty-five (100%) patients. Primary safety composite endpoint (death, stroke, myocardial infarction, device related surgery, cardiac tamponade, renal failure) at 30-days and one-year was 4.4% [95%CI 1.5-16.6] and 17.8% [95%CI 9.3-32.4]. Periprocedural complications occurred in seven patients (15.5% [95%CI 6.5-29.5]) and five patients (11.1% [95%CI 4.9-24.0]) died during one-year follow-up. Paired results for 36 patients demonstrated 24 (66.7%) had Grade 3+/4+ mitral regurgitation at baseline however, only 5 (13.9%) and 3 (8.3%) patients remained at Grade 3+/4+ 30-days and one-year post-procedure (p&lt;0.0001). Echocardiographic parameters such as antero-posterior annulus diameter decreased from 41.4mm (baseline) to 36.0 and 35.3mm at 30-days and one-year respectively <br />(p&lt;0.0001). Twenty-five patients (69.4%) had baseline NYHA Class III/IV symptoms decreasing significantly to 9 (25.0%) at 30-days and 8 (22.2%) at one-year post-procedure (p&lt;0.0001). <br /><br />Conclusion The ARTO&trade; transcatheter mitral valve repair system is both safe and effective in decreasing FMR up to one-year post-procedure. AU - Worthley G. Stephen AU - Redwood R. Simon AU - Hildick-Smith David AU - Rafter Tony AU - Whelan Alan AU - De Marco Federico AU - Horrigan Mark AU - Delacroix Sinny AU - Gregson John AU - Erglis Andrejs VL - IS - Y1 - 28/07/2020 Y1 - 2020 DOI - 10.4244/EIJ-D-20-00484 SP - KW - mitral regurgitation KW - mitral valve repair KW - specific closure device / technique KW - clinical research PB - Europa Digital & Publishing UR - https://eurointervention.pcronline.com/article/transcatheter-reshaping-of-the-mitral-annulus-in-patients-with-functional-mitral-regurgitation-one-year-outcomes-of-the-maveric-trial SN - 1774-024X ER -