TY - JOUR JO - EuroIntervention TI - Clinical Outcomes with Unselected Use of an Ultrathin-Strut Sirolimus-Eluting Stent: A Report from the Swedish Coronary Angiography and Angioplasty Registry (SCAAR) AB - <p><strong>Aims: </strong>To assess the real-world clinical performance of a sirolimus-eluting ultrathin-strut drug-eluting stent (DES) [Orsiro, Biotronik AG] in a large nationwide cohort of patients undergoing percutaneous coronary intervention (PCI).</p> <p><strong>Methods and results:</strong> From the Swedish Coronary Angiography and Angioplasty Registry, the 2-year outcomes of 4,561 patients implanted with Orsiro (Orsiro group) and 69,570 receiving other newer generation DES (n-DES group) were analyzed. The rate of definite stent thrombosis was low in both groups (0.67% and 0.83% for Orsiro and n-DES, respectively; adjusted hazard ratio [HR] 0.90, 95% confidence interval [CI] 0.55-1.46, p-value 0.66). Restenosis was also infrequent (1.5% versus 2.0% with Orsiro and n-DES, adjusted HR 0.81, 95% CI 0.63-1.03, p-value=0.09). The risk of target lesion revascularization by PCI was lower in the Orsiro group (1.6% versus 2.3%, adjusted HR 0.75, 95% CI 0.60-0.94, p-value=0.013). All-cause mortality and myocardial infarction did not show a statistically significant difference between the two groups (mortality of 7.5% in both groups, adjusted HR 0.99, 95% CI 0.72-1.35, p-value=0.94; 6.0% versus 5.2% for myocardial infarction, adjusted HR 1.19, 95% CI 1.00-1.43, p-value=0.06).</p> <p><strong>Conclusions: </strong>In a nationwide scenario, the use of a sirolimus-eluting ultrathin-strut DES portended favorable clinical outcomes.</p> AU - Buccheri Sergio AU - Sarno Giovanna AU - Erlinge David AU - Renlund Henrik AU - Lagerqvist Bo AU - Grimfjärd Per AU - Witt Nils AU - Yndigegn Troels AU - Fröbert Ole AU - Persson Jonas AU - Böhm Felix AU - James K. Stefan VL - IS - Y1 - 06/10/2020 Y1 - 2020 DOI - 10.4244/EIJ-D-20-00429 SP - KW - miscellaneous KW - drug-eluting stent KW - clinical research PB - Europa Digital & Publishing UR - https://eurointervention.pcronline.com/article/clinical-outcomes-with-unselected-use-of-an-ultrathin-strut-sirolimus-eluting-stent-a-report-from-the-swedish-coronary-angiography-and-angioplasty-registry-scaar SN - 1774-024X ER -