TY - JOUR JO - EuroIntervention TI - Impact of bioresorbable scaffold design characteristics on local haemodynamic forces: an ex vivo assessment with computational fluid dynamics simulations AB - <p><strong>Aims:</strong> Bioresorbable scaffold (BRS) regions exposed to flow recirculation, low time-averaged wall shear stress (TAWSS) and high oscillatory shear index (OSI) develop increased neointima tissue. We investigated haemodynamic features in four different BRSs.</p> <p><strong>Methods and results:</strong> Fantom (strut height [SH] = 125 &micro;m), Fantom Encore (SH = 98 &micro;m), Absorb (SH = 157 &micro;m) and Magmaris (SH = 150 &micro;m) BRSs were deployed in phantom tubes and imaged with microCT. Both 2D and 3D geometrical scaffold models were reconstructed. Computational fluid dynamics (CFD) simulation was performed to compute TAWSS and OSI. Thicker struts had larger recirculation zones and lower TAWSS in 2D. Absorb had the largest recirculation zone and the lowest TAWSS (240 &micro;m and &minus;0.18 Pa), followed by Magmaris (170 &micro;m and &minus;0.15 Pa), Fantom (140 &micro;m and &minus;0.14 Pa) and Fantom Encore (100 &micro;m and &minus;0.13 Pa). Besides strut size, stent design played a dominant role in 3D. The highest percentage area adverse TAWSS (&lt;0.5 Pa) and OSI (&gt;0.2) were found for Fantom (56% and 30%) and Absorb (53% and 33%), followed by Fantom Encore (30% and 25%) and Magmaris (25% and 20%). Magmaris had the smallest areas due to a small footprint and rounded struts.</p> <p><strong>Conclusions:</strong> Due to stent design, both Fantom Encore and Magmaris showed smaller TAWSS and OSI than Fantom and Absorb. This study quantifies which scaffold features are most important to reduce long-term restenosis.</p> AU - Tarrahi Imane AU - Colombo Monika AU - Hartman M.J. Eline AU - Tovar Forero Natalia Maria AU - Torii Ryo AU - Chiastra Claudio AU - Daemen Joost AU - Gijsen J.H. Frank VL - 16 IS - 11 Y1 - 04/12/2020 Y1 - 2020 DOI - 10.4244/EIJ-D-19-00657 SP - e930 EP - e937 KW - bioresorbable scaffolds KW - in-stent restenosis KW - preclinical research PB - Europa Digital & Publishing SE - Coronary interventions - Mini focus on bioresorbable scaffolds UR - https://eurointervention.pcronline.com/article/impact-of-bioresorbable-scaffold-design-characteristics-on-local-hemodynamic-forces-an-ex-vivo-assessment-with-computational-fluid-dynamics-simulations SN - 1774-024X ER -