TY - JOUR JO - EuroIntervention TI - Outcomes of optical coherence tomography compared with intravascular ultrasound and with angiography to guide coronary stent implantation: one-year results from the ILUMIEN III: OPTIMIZE PCI trial AB - <p><strong>Aims:</strong> In the ILUMIEN III trial, among 450 randomised patients with non-complex lesions undergoing percutaneous coronary intervention (PCI), optical coherence tomography (OCT) guidance led to greater stent expansion than angiography guidance, similar minimal stent area compared to both intravascular ultrasound (IVUS) guidance and angiography guidance, and lower rates of uncorrected dissection and malapposition than both IVUS guidance and angiography guidance. Whether these differences impact on clinical outcomes is unknown. The aim of the present study was to report the 12-month clinical follow-up data from the ILUMIEN III study.</p> <p><strong>Methods and results:</strong> OCT-guided PCI, using an external elastic lamina-based protocol, was compared to operator-directed IVUS-guided or angiography-guided PCI. Target lesion failure (TLF) and major adverse cardiovascular events (MACE) at 12 months were adjudicated by a blinded clinical events committee. There were no significant differences in the rates of TLF (2.0% OCT, 3.7% IVUS, 1.4% angiography), MACE (9.8% OCT, 9.1% IVUS, 7.9% angiography), or any of the individual components of these outcomes among the groups. No independent predictors of 12-month stent-related clinical events were identified from final OCT.</p> <p><strong>Conclusions:</strong> In this underpowered study, OCT-guided PCI of non-complex lesions did not show a statistical difference in clinical outcomes at 12 months compared with IVUS or angiography guidance. An appropriately powered trial, including only complex patients and lesions, is underway to substantiate the potential clinical benefit of OCT-guided PCI. Trial registration: NCT02471586</p> AU - Ali Ziad A. AU - Karimi Galougahi Keyvan AU - Maehara Akiko AU - Shlofmitz Richard A. AU - Fabbiocchi Franco AU - Guagliumi Giulio AU - Alfonso Fernando AU - Akasaka Takashi AU - Matsumura Mitsuaki AU - Mintz Gary S. AU - Ben-Yehuda Ori AU - Zhang Zhen AU - Rapoza J. Richard AU - West E.J. Nick AU - Stone W. Gregg VL - 16 IS - 13 Y1 - 20/01/2021 Y1 - 2021 DOI - 10.4244/EIJ-D-20-00498 SP - 1085 EP - 1091 KW - clinical trials KW - intravascular ultrasound KW - optical coherence tomography KW - percutaneous coronary intervention PB - Europa Digital & Publishing SE - Coronary interventions UR - https://eurointervention.pcronline.com/article/outcomes-of-optical-coherence-tomography-compared-with-intravascular-ultrasound-and-with-angiography-to-guide-coronary-stent-implantation-one-year-results-from-the-ilumien-iii-optimize-pci-trial SN - 1774-024X ER -