TY - JOUR JO - EuroIntervention TI - Heterogeneity of debris captured by cerebral embolic protection filters during TAVI AB - <p><strong>Aims:</strong> The aim of this study was to investigate the total amount, size and heterogeneity of debris captured among different transcatheter valve types and while repositioning.</p> <p><strong>Methods and results:</strong> A total of 328 patients who underwent transcatheter aortic valve implantation (TAVI) with the SENTINEL cerebral embolic protection (CEP) at our centre were eligible. Histopathological and semiquantitative analysis of captured debris was performed and data were entered into our prospective database. TAVI was performed with either the Evolut R/PRO (N=123), SAPIEN 3 (N=113) or Lotus valve (N=92). Capture of debris occurred in 98% of patients. Lotus TAVI resulted in more frequent foreign body material (62% vs 40% vs 47%, p=0.006), endothelium (49% vs 30% vs 16%, p&lt;0.0005), calcified material (33% vs 12% vs 24%, p=0.001) and myocardial tissue (19% vs 11% vs 2%, p&lt;0.0005) compared to SAPIEN 3 or Evolut R/PRO. Native (functional) bicuspid valves (OR 2.91, 95% CI: 1.20-7.03, p=0.02) and Lotus (OR 2.44, 95% CI: 1.14-5.24, p=0.02) were associated with the highest risk for dislodging particles &ge;1,000 um. Valve repositioning was independently associated with larger amounts of debris (OR 2.96, 95% CI: 1.42-6.16, p=0.004).</p> <p><strong>Conclusions:</strong> All THV platforms had similar amounts of captured debris. THV repositioning seemed to be associated with a higher risk for dislodging greater amounts of debris to the brain.</p> <p><img src="https://files.eurointervention.com/issues/EIJ183/206_EIJ-D-20-00744_Kroon_183/image/visual_summary/00_Kroon_183.png" alt="" /></p> <p class="VisualSummary"><strong>Visual summary.</strong> Aetiopathology of debris captured by cerebral embolic protection filters during TAVI, including risk factors for greater amounts or larger particles of debris.</p> AU - Kroon G. Herbert AU - von der Thusen H. Jan AU - Ziviello Francesca AU - van Wiechen Maarten AU - Ooms F. Joris AU - Kardys Isabella AU - Schipper Marguerite AU - van Gils Lennart AU - Daemen Joost AU - de Jaegere P. Peter AU - Van Mieghem Nicolas M. VL - 16 IS - 14 Y1 - 19/02/2021 Y1 - 2021 DOI - 10.4244/EIJ-D-20-00744 SP - 1141 EP - 1147 KW - aortic stenosis KW - cerebral protection KW - ischaemic stroke KW - tavi PB - Europa Digital & Publishing SE - Interventions for valvular disease and heart failure UR - https://eurointervention.pcronline.com/article/heterogeneity-of-debris-captured-by-cerebral-embolic-protection-filters-during-tavi SN - 1774-024X ER -