TY - JOUR JO - EuroIntervention TI - Prognostic significance of thermodilution-derived coronary flow capacity in patients with deferred revascularisation AB - <p><strong>Aims:</strong> The aim of this study was to investigate the prognostic value of thermodilution-derived coronary flow capacity (T-CFC) in patients with stable coronary artery disease and deferred revascularisation.</p> <p><strong>Methods and results:</strong> We evaluated 308 lesions in 308 patients with deferred revascularisation, stratifying the cohort according to T-CFC. Ischaemic T-CFC was defined as a composite of mildly, moderately, and severely reduced T-CFC. Clinical outcomes were assessed by vessel-oriented composite endpoints (VOCE) and major adverse cardiac events (MACE). VOCE and MACE occurred in 19 and 28 patients, respectively. Ischaemic T-CFC was found in 88 lesions (28.6%). Kaplan-Meier analysis revealed that lesions with ischaemic T-CFC had a significantly higher risk of both VOCE and MACE. The net reclassification index and integrated discrimination improvement index were both significantly improved when ischaemic T-CFC was added to the clinical risk model (age, sex, prior stent implantation, and lesion length) for predicting VOCE and MACE. Furthermore, ischaemic T-CFC showed significant incremental predictive ability for VOCE and MACE when compared with the clinical risk model + fractional flow reserve &le;0.8, or with the clinical model + coronary flow reserve &le;2.0.</p> <p><strong>Conclusions:</strong> T-CFC categorisation improved the risk stratification for both VOCE and MACE and showed incremental prognostic value in patients with deferred revascularisation.</p> AU - Hoshino Masahiro AU - Kanaji Yoshihisa AU - Hamaya Rikuta AU - Kanno Yoshinori AU - Hada Masahiro AU - Yamaguchi Masao AU - Sumino Yohei AU - Usui Eisuke AU - Murai Tadashi AU - Lee Tetsumin AU - Yonetsu Taishi AU - Kakuta Tsunekazu VL - 16 IS - 14 Y1 - 19/02/2021 Y1 - 2021 DOI - 10.4244/EIJ-D-19-00029 SP - 1195 EP - 1203 KW - fractional flow reserve KW - ischaemic cardiomyopathy KW - stable angina PB - Europa Digital & Publishing SE - Coronary interventions UR - https://eurointervention.pcronline.com/article/prognostic-value-of-thermodilution-derived-coronary-flow-capacity-in-patients-with-deferred-revascularization SN - 1774-024X ER -