TY - JOUR JO - EuroIntervention TI - Optimising physiological endpoints of percutaneous coronary intervention AB - <p>Invasive coronary physiology to select patients for coronary revascularisation has become established in contemporary guidelines for the management of stable coronary artery disease. Compared to revascularisation based on angiography alone, the use of coronary physiology has been shown to improve clinical outcomes and cost efficiency. However, recent data from randomised controlled trials have cast doubt upon the value of ischaemia testing to select patients for revascularisation. Importantly, 20-40% of patients have persistence or recurrence of angina after angiographically successful percutaneous coronary intervention (PCI). This state-of-the-art review is focused on the transitioning role of invasive coronary physiology from its use as a dichotomous test for ischaemia with fixed cut-points, towards its utility for real-time guidance of PCI to optimise physiological results. We summarise the contemporary evidence base for ischaemia testing in stable coronary artery disease, examine emerging indices which allow advanced physiological guidance of PCI, and discuss the rationale and evidence base for post-PCI physiological assessments to assess the success of revascularisation.</p> AU - Al-Lamee K. Rasha AU - Rajkumar Christopher A. AU - Ganesananthan Sashiananthan AU - Jeremias Allen VL - 16 IS - 18 Y1 - 02/04/2021 Y1 - 2021 DOI - 10.4244/EIJ-D-20-00988 SP - e1470 EP - e1483 KW - clinical trials KW - fractional flow reserve KW - stable angina PB - Europa Digital & Publishing SE - State of the Art UR - https://eurointervention.pcronline.com/article/optimising-physiological-endpoints-of-percutaneous-coronary-intervention SN - 1774-024X ER -