TY - JOUR JO - EuroIntervention TI - Impact of left ventricular outflow tract calcification in patients undergoing transfemoral transcatheter aortic valve implantation AB - <p><strong>Background:</strong> Left ventricular outflow tract (LVOT) calcification is known to be associated with adverse outcomes after transcatheter aortic valve implantation (TAVI) in patients receiving first-generation transcatheter heart valves (THV).</p> <p><strong>Aims:</strong> The aim of the present study was to assess the prevalence of LVOT calcification as well as its impact on outcomes in a contemporary TAVI patient cohort.</p> <p><strong>Methods:</strong> This retrospective single-centre analysis includes 1,207 patients who underwent transfemoral TAVI between 2012 and 2018 and in whom adequate contrast-enhanced MSCT imaging for quantification of LVOT calcification was available.</p> <p><strong>Results:</strong> Significant LVOT calcification, defined as &gt;10 mm<sup>3</sup>, was present in 37.4% (n=451) of the patient cohort. After applying propensity score matching there was no difference between patients without (w/o; n=358) and with (w; n=358) significant LVOT calcification with respect to baseline clinical characteristics. At 30 days, the composite of all-cause mortality and non-disabling/disabling stroke occurred more often in patients w LVOT calcification compared to those w/o (4.6 vs 10.1%, p=0.008). Moreover, the composite VARC-3 endpoint of device success at 30 days was in favour of patients w/o LVOT calcification (82.2% vs 73.4%, p=0.007). According to Kaplan-Meier analysis, all-cause mortality one year after TAVI was higher in patients w vs w/o LVOT calcification (12.9 vs 21.4 %, p=0.004).</p> <p><strong>Conclusions:</strong> In patients undergoing TAVI, the presence of significant LVOT calcification is common and associated with worse short-term clinical and functional outcomes as well as higher one-year mortality rates compared to patients w/o LVOT calcification.</p> AU - Waldschmidt Lara AU - Goßling Alina AU - Ludwig Sebastian AU - Linder Matthias AU - Voigtländer Lisa AU - Grundmann David AU - Bhadra Daniel Oliver AU - Demal Till AU - Schirmer Johannes AU - Reichenspurner Hermann AU - Blankenberg Stefan AU - Westermann Dirk AU - Seiffert Moritz AU - Conradi Lenard AU - Schofer Niklas VL - IS - Y1 - 19/10/2021 Y1 - 2021 DOI - 10.4244/EIJ-D-21-00464 SP - KW - aortic stenosis KW - tavi KW - femoral KW - msct PB - Europa Digital & Publishing UR - https://eurointervention.pcronline.com/article/impact-of-left-ventricular-outflow-tract-calcification-in-patients-undergoing-transfemoral-transcatheter-aortic-valve-implantation SN - 1774-024X ER -