TY - JOUR JO - EuroIntervention TI - Optical flow ratio for assessing stenting result and physiological significance of residual disease AB - <p><strong>Background:</strong> Optical flow ratio (OFR) is a novel method for fast computation of fractional flow reserve (FFR) from optical coherence tomography (OCT) images.</p> <p><strong>Aims:</strong> We aimed to evaluate the accuracy of OFR in predicting post-percutaneous coronary intervention (PCI) FFR and the impact of stent expansion on within-stent OFR pressure drop (in-stent OFR).</p> <p><strong>Methods:</strong> Post-PCI OFR was computed in patients with both OCT and FFR interrogation immediately after PCI. Calculation of post-PCI OFR (called simulated residual OFR) from pre-PCI OCT pullbacks after elimination of the stenotic segment by virtual stenting was performed in a subgroup of patients who had pre-PCI OCT images. Stent underexpansion was quantified by the minimum expansion index (MEI) of the stented segment.</p> <p><strong>Results:</strong> A total of 125 paired comparisons between post-PCI OFR and FFR were obtained in 119 patients, among which simulated residual OFR was obtained in 64 vessels. Mean post-PCI FFR was 0.92&plusmn;0.05. Post-PCI OFR showed good correlation (r=0.74, p&lt;0.001) and agreement (mean difference=&ndash;0.01&plusmn;0.03, p=0.051) with FFR. The accuracy in predicting post-PCI FFR &le;0.90 was 84% for post-PCI OFR. Simulated residual OFR significantly correlated with post-PCI FFR (r=0.42, p&lt;0.001). MEI showed a moderate correlation (r=&ndash;0.49, p&lt;0.001) with in-stent OFR.</p> <p><strong>Conclusions:</strong> Post-PCI OFR showed good diagnostic concordance with post-PCI FFR. Simulated residual OFR significantly correlated with post-PCI FFR. Stent underexpansion significantly correlated with in-stent pressure drop.</p> AU - Ding Daixin AU - Yu Wei AU - Tauzin Hélène AU - De Maria Luigi Giovanni AU - Wu Peng AU - Yang Fan AU - Kotronias A. Rafail AU - Terentes-Printzios Dimitrios AU - Wolfrum Mathias AU - Banning P. Adrian AU - Meneveau Nicolas AU - Wijns William AU - Tu Shengxian VL - 17 IS - 12 Y1 - 17/12/2021 Y1 - 2021 DOI - 10.4244/EIJ-D-21-00185 SP - e989 EP - e998 KW - acs/nste-acs KW - fractional flow reserve KW - optical coherence tomography KW - stable angina PB - Europa Digital & Publishing SE - Coronary interventions UR - https://eurointervention.pcronline.com/article/optical-flow-ratio-for-assessing-stenting-result-and-physiological-significance-of-residual-disease SN - 1774-024X ER -