TY - JOUR JO - EuroIntervention TI - Coronary vasomotion after treatment with drug-coated balloons or drug-eluting stents: a prospective, open-label, single-centre randomised trial AB - <p><strong>Background:</strong> Although recent studies have reported that drug-coated balloons (DCB) are non-inferior to drug-eluting stents (DES) for the treatment of native coronary arteries in a specific population, there is no available information concerning vasomotion after treatment with DCB.</p> <p><strong>Aims:</strong> The aim of this study was to prospectively compare coronary vasomotion in patients with small coronary artery disease treated with DCB versus DES.</p> <p><strong>Methods:</strong> Forty-two native lesions (2.0-3.0 mm) treated in our institution were randomly assigned to the DCB arm (n=19) or the bioabsorbable polymer everolimus-eluting stents arm (n=23) after successful predilation. At eight months after treatment, endothelium-dependent and -independent vasomotion was evaluated with intracoronary infusions in incremental doses of acetylcholine (right coronary artery: low dose 5 &mu;g, high dose 50 &mu;g; left coronary artery: low dose 10 &mu;g, high dose 100 &mu;g) and nitroglycerine (200 &mu;g). The mean lumen diameter of the distal segment, beginning 5 mm and ending 15 mm distal to the edge of the treated segment, was quantitatively measured by angiography.</p> <p><strong>Results:</strong> The luminal dimension in the treated segment did not differ between groups at the follow-up angiography. The vasoconstriction after acetylcholine infusion was less pronounced in the DCB arm than in the DES arm (low-dose: 6&plusmn;13% vs &ndash;3&plusmn;18%, p=0.060; high-dose: &ndash;4&plusmn;17% vs &ndash;21&plusmn;29%, p=0.035). The response to nitroglycerine did not differ between groups (17&plusmn;13% vs 17&plusmn;22%, p=0.929).</p> <p><strong>Conclusions:</strong> Vasoconstriction after acetylcholine infusion in the peri-treated region was less pronounced in the DCB arm than in the DES arm, suggesting that endothelial function in treated coronary vessels could be better preserved by DCB than by new-generation DES.</p> AU - Kawai Tsutomu AU - Watanabe Tetsuya AU - Yamada Takahisa AU - Morita Takashi AU - Furukawa Yoshio AU - Tamaki Shunsuke AU - Kawasaki Masato AU - Kikuchi Atsushi AU - Seo Masahiro AU - Nakamura Jun AU - Tachibana Kentaro AU - Kida Hirota AU - Sotomi Yohei AU - Sakata Yasushi AU - Fukunami Masatake VL - 18 IS - 2 Y1 - 03/06/2022 Y1 - 2022 DOI - 10.4244/EIJ-D-21-00636 SP - e140 EP - e148 KW - drug-coated balloon KW - drug-eluting stent KW - qca KW - stable angina PB - Europa Digital & Publishing SE - Coronary interventions - Mini focus on drug-eluting stents and drug-coated balloons UR - https://eurointervention.pcronline.com/article/coronary-vasomotion-after-treatment-with-drug-coated-balloons-or-drug-eluting-stents-a-prospective-open-label-single-centre-randomised-trial SN - 1774-024X ER -